All 5 Safe Codes in Resident Evil Requiem — Normal & Insanity

Every safe combination in Resident Evil Requiem (RE9) for both Normal and Insanity difficulty. Opening all 5 safes unlocks the "No Safe Is Safe" trophy and rewards crucial Antique Coins, ammo, and healing items. Only Grace can open safes — Leon cannot.

Quick reference: All safes at a glance

If you're speedrunning or just want the codes fast, here's the complete list. Detailed locations and rewards follow below.

Safe #1 — Bar & Lounge // CARE CENTER WEST WING

The first safe most players will encounter, located in the West Wing of the Care Center. Easy to miss because it's hidden behind the bar counter.

Safe #2 — Examination Room // CARE CENTER EAST WING 1F

Located in the Examination Room on the East Wing's first floor. Tucked into a corner cabinet that's easy to walk past.

Safe #3 — Furnace Room // CARE CENTER BASEMENT

One of the harder safes to access — requires the Level 1 Wristband from solving the first Quartz Puzzle Box on East Wing 2F. Don't try to reach this safe before completing that puzzle.

Safe #4 — Sterilization Chamber // CARE CENTER STERILIZATION

This safe contains some of the best mid-game rewards in the Care Center, including Hemolytic Injectors that one-shot mini-bosses like Chunk and the Chef.

Safe #5 — Monitor Control Room // RACCOON CITY

The final safe is in Raccoon City, far from the Care Center. Highly missable — you can't return here once you progress past the Bioweapon Repository sequence.

Tips, tricks, and trophy reward

// HOW TO INPUT SAFE CODES

Approach the safe and interact with it. The dial puzzle screen appears. Use these inputs:

• L (Left) = rotate dial clockwise
• R (Right) = rotate dial counterclockwise
• Stop precisely on the listed number — overshooting does not work, you must exit and retry
• Press the Check / Confirm button after entering all three numbers

// WHY ONLY GRACE CAN OPEN SAFES

Safe-cracking is one of Grace Ashcroft's character-specific abilities, like Blood Crafting. Leon cannot interact with safes at all — he won't even see the prompt. If you're playing as Leon and trying to open a safe, switch back to Grace's section in the story or use a Grace-only save.

// "NO SAFE IS SAFE" TROPHY

Opening all 5 safes (regardless of difficulty) unlocks the "No Safe Is Safe" Silver trophy. This is one of the easier collectible-based trophies in the game if you have this guide handy. Combine it with the Mr. Raccoon collectible run for an efficient cleanup pass.

// WHAT TO DO WITH ANTIQUE COINS

The 12+ Antique Coins from safes should be spent at The Parlor in the West Wing. The Parlor merchant offers:

• Weapon attachments (scopes, extended mags, suppressors)
• Healing items at discounted rates
• Crafting materials for Grace's Blood System
• Rare cosmetics for post-game

Don't hoard coins — there are more than enough in the game to fully stock up at the Parlor.

Speedrun strategy: Memorize codes, skip clues

For Insanity speedrun attempts, memorizing all 5 codes from this guide saves significant time. The code clues are scattered across optional rooms — skipping them and entering codes directly cuts roughly 8-10 minutes off a typical Care Center run.

Recommended speedrun order:

1. Safe #1 (Bar & Lounge) — accessible in early Care Center exploration
2. Safe #2 (Examination Room) — same area, same trip
3. Safe #3 (Furnace Room) — after getting Level 1 Wristband
4. Safe #4 (Sterilization Chamber) — same area as Safe #3
5. Safe #5 (Monitor Control Room) — Raccoon City, last opportunity

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