RE9 Missables Complete Guide — All Missable Collectibles, Trophies & Events

In Resident Evil Requiem (RE9), a single wrong turn or skipped step can permanently lock collectibles, one-time events, or even trophies. This guide maps every missable in the campaign — chapter by chapter — so you can hit 100% completion on your first playthrough.

Why missables matter in RE9

Unlike most modern Resident Evil entries, RE9 has multiple one-way chapter transitions. Once you leave a chapter, every collectible, event, and trophy gated to that chapter is permanently closed for that playthrough. For trophy hunters this is especially brutal — some trophies are only obtainable within a single chapter window.

This guide covers 4 categories of missables:

• Collectible locks: Mr. Raccoon dolls, antique coins, files, weapons inaccessible after chapter end
• One-time events: NPC dialogues, environmental interactions, cutscene variants
• Trophy locks: Trophies that can only be earned within specific chapters
• Weapon/tool locks: Limited pickups only available during one chapter

Critical 7 — never miss these

1. Safes #1-#4 (Care Center) — Open all four before entering the Courtyard. Safe codes guide
2. Eye Spy Charm — Reward from Chunk #1 (Care Center East Wing 2F). Lifesaver on Insanity.
3. Mortal Edge Hatchet — Reward from The Commander (ARK interior). Essentially required for Victor Gideon.
4. Marksman 1A Rifle — Back room of Hank's Pawn (Raccoon City North district). Critical for Plant 43 + Victor Gideon.
5. ARK Keycard — Raccoon City West district train station. Required to enter ARK Facility.
6. Orphanage Keepsake — Chapter 6 only. Triggers NG+ alternate ending.
7. Hemorrhetic Injectors — One-shot kill key for Chef/Chunk. Stockpile in early chapters.

Chapter 1: Wrenwood Hotel

Relatively safe chapter, but several missables:

• Handgun — 1F front desk (unmissable)
• Herb pouches — 2F Manager's Office — missed if you skip the office
• Mr. Raccoon #1 — 3F suite room ceiling vent (requires explosive damage from grenade or RPG)
• Rooftop cutscene variant — Wait 5 seconds on the roof for an extra NPC line

Chapter 2: Care Center (most missable-rich chapter)

The Care Center is the campaign's first major sandbox and contains the most missables of any chapter. See Care Center walkthrough for full step-by-step routing.

• Safe #1 (Bar & Lounge / Café) — Reward: 3× antique coins
• Safe #2 (Examination Room) — Reward: magnum ammo
• The Chef boss (optional) — Killing him drops Pantry Key + "First Blood" trophy
• Chunk #1 Thomas (East Wing 2F) — Killing him drops Eye Spy Charm (Insanity-critical)
• Mr. Raccoon #2-#5 — Scattered across the Care Center
• Antique coins #1-#4
• Files #1-#8

Chapter 3: Care Center Basement

• Safe #3 (Furnace Room) + Safe #4 (Sterilization Chamber / Lab Safe)
• Chunk #2 Timothy (mandatory) — Reward: MSBG 500 shotgun upgrade
• Quartz Pieces ×2 — Required for Courtyard fountain puzzle
• Artificial Heart + Lungs — Organless corpse puzzle

Chapter 4: Courtyard

• Blister-borne boss (mandatory) — Reward: Mortal Edge Hatchet upgrade
• Courtyard fountain Quartz puzzle — Eye Spy Charm refill + antique coin
• Chapel save room — Only save point

Chapter 5: Water Treatment Plant

• The Girl boss (mandatory) — Reward: Sunlight Lens
• 3 sunlight units restart order — Fixed sequence (A → C → B)
• Valve codes — Normal (A=3 B=7 C=5), Insanity (A=4 B=2 C=8)

Chapter 6: RPD & Orphanage

• Kendo Custom Handgun — Kendo Gun Shop (2 blocks east of RPD). Significantly stronger sidearm.
• Safe #5 (Monitor Control Room / Observation Room) — Open before Mr. X spawns
• Mr. Raccoon #11 — Kendo Gun Shop sign (shoot from outside)
• Orphanage Keepsake — Headmistress' office. Triggers NG+ alternate ending.
• Orphanage files ×3 — Narrative connectors back to Wrenwood Hotel intro
• Memorial trophy — Orphanage only

Chapter 7: Raccoon City Square

• Marksman 1A Rifle — Hank's Pawn back room (North district)
• Mr. Raccoon #15-#17 — Scattered across all 4 districts
• ARK Keycard — Train station locomotive (West district) — mandatory
• Final Quartz Piece — Mall escalator pit (South district)
• Safe #5 alternate location — Bonus content if all 4 prior safes were opened

Chapter 8: ARK Facility

• Mr. Raccoon #22-#24 — Lab levels (#23 is the most missable — on the ARK Director's desk)
• Final antique coins ×4 — Hidden inside lab equipment
• NG+ RNA puzzle — NG+ only (Director's office) — see RNA puzzle guide
• Alternate ending — Requires both Orphanage Keepsake + correct RNA puzzle answer

Missable trophies

These trophies can only be earned within specific chapters. Missing them requires NG+ or (when unlocked) chapter select:

• First Blood (Bronze) — Defeat The Chef in Chapter 2
• Locked & Loaded (Bronze) — Defeat Chunk #1 in Chapter 2
• Memorial (Silver) — Collect Orphanage Keepsake in Chapter 6
• Open-Air Surgeon (Bronze) — 4-cyst Blister-borne kill in Chapter 4
• Anatomy 101 (Bronze) — Complete organless corpse puzzle in Chapter 3
• Light of Day (Silver) — Defeat The Girl in Chapter 5

Full 49-trophy roadmap: 49 Trophies + Platinum guide

Tips to never miss anything

1. Save in a new slot at the start of every chapter — gives you a backtrack point if you realize you missed something
2. Check the chapter checklist on this page before triggering any chapter-transition cutscene (keep this page open on mobile)
3. Insanity-run players: follow this guide religiously — Insanity's chapter-select unlocks are inconvenient
4. NG+ can recover most misses — but trophies count per-playthrough, so plan accordingly
5. Microsoft Clarity data from our user base shows the highest 100%-completion failure rate is in Chapters 2 and 6 — be extra thorough in those two