Care Center Basement Walkthrough — Resident Evil Requiem (RE9)

The Care Center Basement is the lab section underneath the Rhodes Hill Care Center. This RE9 walkthrough covers the organless corpse puzzle (Artificial Heart + Lungs), the blood specimen analyzer, the Chunk #2 (Timothy B. Jackson) attic encounter, and the Quartz puzzle pieces leading to the sewer transition.

Lab descent overview

The Care Center Basement is where Resident Evil Requiem starts taking off the gloves. Leon descends into a derelict pharmaceutical lab where the Raccoon Strain was first isolated, and you transition from the relatively-safe upper floors into a tight, ammo-light environment full of mandatory puzzles and one of the harder mid-game boss fights.

Plan to enter this chapter with at least 40 handgun rounds, 2 First Aid Sprays, and 3+ Hemorrhetic Injectors. If you missed any of those upstairs, double back before the laundry-chute drop — there is no return until after Chunk #2.

Descent from the East Wing

There are two ways into the basement. The laundry chute on East Wing 1F is a one-way drop — fast but it locks you out of the upper floors until you complete this chapter. The maintenance staircase at the end of the East Wing 2F hallway is slower but reversible.

1. If you still need the East Wing 2F safe (Safe #2), take the staircase. The laundry chute leaves it permanently out of reach for this run.
2. If you have everything you need, the chute is the faster route and drops you next to the first save room.
3. Use the save room immediately — the next 30 minutes are unsafe.

Lab corridors: the organless corpse puzzle

The west lab corridor ends at the Anatomy Room, which contains the famous organless corpse puzzle. The body on the slab is missing both an artificial heart and a pair of artificial lungs, and the door beyond won't open until you place both.

1. Artificial Heart — locked in the wall cabinet across from the slab. The key is in the desk drawer of the adjacent Records Office.
2. Artificial Lungs — sitting on the upper shelf of the storage closet to the east. Push the rolling ladder over to reach them.
3. Insert both in the corpse (heart first, then lungs). The door clicks open and the corpse drops a Hemorrhetic Injector.

For step-by-step images of the symbol orientation, see our full puzzle solutions hub.

Blood Specimen Analyzer puzzle (Sterilization Chamber)

Through the corpse door is the Sterilization Chamber clean zone. The Blood Specimen Analyzer terminal is on the right wall. You need to click the correct three squares of a 4×4 grid to unlock the inner lab — get it wrong and the chamber's decon spray bursts in your face (light damage but it wastes time).

Get this right and the inner lab opens. Inside: an MSBG 500 shotgun upgrade attachment, two crafting components, and the first of two Quartz Pieces for this chapter.

Chunk #2 boss encounter (Timothy B. Jackson)

The attic above the Sterilization Chamber is the arena for the Chunk #2 fight — the larger of the two Chunk variants and the first proper boss of the basement. Timothy B. Jackson is mandatory; you cannot skip this fight to continue.

The MSBG 500 shotgun next to the dead orderly at the arena entrance is the key. Pick it up before triggering the cutscene. Full strategy in our Chunk boss guide.

Sterilization Chamber: hidden safe + files

After Chunk #2 falls, the attic gate slides open and you can drop back into the Sterilization Chamber. The decon system is off now — the chamber is safe to wander.

• Hidden safe behind the locker panel on the south wall (push the panel left). Code is in our safe codes guide. Reward: tactical knife + 3× gunpowder.
• File: Lead Researcher's Journal — desk in the inner lab. Counts toward the 75 files trophy.
• Mr. Raccoon #6 — under the decon shower. Easy to miss.
• Second Quartz Piece — sitting on the cleared corpse from the puzzle.

Sewer transition to the Courtyard

The basement's east passage ends at a flooded sewer hatch. Use the Quartz Pieces collected this chapter to unlock the wheel mechanism (insert both into the pedestal slots — the order is shown by the wall etching).

The hatch opens onto a short ladder down to the Care Center Courtyard, where the Blister-borne fight is waiting.

What comes next: the Courtyard

The Courtyard chapter is shorter than the basement but introduces the four-cyst Blister-borne pattern that you'll see again in the sewers leading to Raccoon City. Stock up on whatever ammo you can craft from this chapter's drops before climbing down.

Continue with our Care Center Courtyard walkthrough, or jump ahead to the Blister-borne boss guide if you only need the fight tactics.