Author note: Written by Jachin, a 23-year Resident Evil series fan based in Seoul, South Korea. This guide is based on 6 full RE9 playthroughs on PS5 and Steam (Casual → Insanity → NG+ Insanity completions). All strategies, timings, and locations have been personally tested across the v1.02 patch. AI tools were used only for grammar review and note organization; no AI-generated content appears in strategy analysis.
Verified on: v1.02 + DLC patch · Last reviewed: May 30, 2026 · About the author · Editorial policies
The Hand Cannon Prototype is Grace’s exclusive heavy weapon — found in Vivien’s lab during ARK Facility. 350 base damage, single-shot reload. Limited to 8 total rounds in the game. Save for boss fights. Best vs Plant 43 core and Victor Gideon Phase 1.
This weapon serves a specific tactical role in RE9. Read on for stats, upgrade path, and best use cases.
See the location and prerequisites in the relevant area walkthrough.
Pairs well with Crafter’s Touch (ammo crafting) and Iron Skin (defensive). Adjust based on playstyle.
Refer to the bosses tier list and our individual boss guides for specific weapon recommendations.
Tested across all Insanity NG+ runs. Works as designed when paired with appropriate charms.
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